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Ethambutol is rapidly and 80% absorbed from the digestive tract. The minimum inhibitory concentration is 1 mg / ml.

After oral administration of a single dose of 25 mg / kg body weight after 2-4 hours, Cmax in serum of 2-5 μg / ml is achieved, after 24 hours the concentration is less than 1 μg / ml.

20-30% bound to plasma proteins.

Ethambutol is metabolized in the liver to dicarboxylic acid derivatives. T1 / 2 is 3-4 hours, and in case of renal failure it lengthens up to 8 hours. Within 24 hours more than the accepted 50% of the dose is excreted unchanged in the urine, and 8-15% in the form of inactive metabolites. About 20-22% of the initial dose of the drug is excreted in feces unchanged.

Ethambutol crosses the placenta. In the fetal blood, the concentration of ethambutol c leaves approximately 30% of the concentration of the drug in the mother’s blood.


Manufacturer Riemser Pharma GmbH Germany