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Ethambutol is rapidly and 80% absorbed from the digestive tract. The minimum inhibitory concentration is 1 mg / ml.

After oral administration of a single dose of 25 mg / kg body weight after 2-4 hours, Cmax in serum of 2-5 μg / ml is achieved, after 24 hours the concentration is less than 1 μg / ml.

20-30% bound to plasma proteins.

Ethambutol is metabolized in the liver to dicarboxylic acid derivatives. T1 / 2 is 3-4 hours, and in case of renal failure it lengthens up to 8 hours. Within 24 hours more than the accepted 50% of the dose is excreted unchanged in the urine, and 8-15% in the form of inactive metabolites. About 20-22% of the initial dose of the drug is excreted in feces unchanged.

Ethambutol crosses the placenta. In the fetal blood, the concentration of ethambutol c leaves approximately 30% of the concentration of the drug in the mother’s blood.


Manufacturer Riemser Pharma GmbH Germany


tuberculosis of any localization, in adults and children, treatment and prevention, including as part of combination therapy.

Anti-tuberculosis product. The active substance of the drug - isoniazid acts bactericidal, inhibits the synthesis of mycolic acids, which are the most important component of the cell wall of mycobacteria. It is especially active against rapidly multiplying microorganisms (including those located intracellularly).

Tuberculosis (all forms) - as part of combination therapy. Leprosy (in combination with dapsone - multibacillary types of the disease).


Manufacturer Riemser Pharma GmbH Germany